Serveur d'exploration sur la maladie de Parkinson

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Parkinson's disease incidence: magnitude, comparability, time trends

Identifieur interne : 002690 ( Main/Exploration ); précédent : 002689; suivant : 002691

Parkinson's disease incidence: magnitude, comparability, time trends

Auteurs : J. De Pedro-Cuesta [Suède, Espagne] ; L. Stawiarz [Suède]

Source :

RBID : ISTEX:6ABA790F8D0A1E0FB6598FFE9C9B49365D1D13CE

English descriptors

Abstract

ABSTRACT In this study, we reviewed incidence surveys of Parkinson's Disease (PD) from all over the world, published during the period 1945‐1989, using reported quality criteria. In addition, we compared age‐specific PD incidences from selected observations by stratified analysis. Crude incidences were described for 11 populations, and age‐specific incidences for three of them: Iceland, Rochester (Minn, USA), and Turku (Finland). Effect modification by age was detected: a) by comparing incidences by age at diagnosis with incidence by age at clinical disease onset; and b) when only data on onset of disease was computed. For disease onsets, the incidences in Rochester for the period 1955‐1966, and in Turku (Finland) during the interval 1968‐1970, were lower than that in Iceland for the period 1958‐1960: RR=0.58 95% CI (0.41, 0.83), and RR=0.67 95% CI (0.51, 0.87), respectively. For the Rochester population aged 40‐69 years, a statistically significant 56% decrease in the incidences of Parkinsonism onsets during the period 1945‐1966 was found. Validity problems in comparing PD incidences and the role of PD underdiagnosis were emphasized. We concluded that: a) stratified analysis is more suitable than standardization when comparing incidences for etiological purposes; b) the incidence of PD was highest in Iceland; and c) in Rochester, PD incidence under the age of 70 decreased with time.

Url:
DOI: 10.1111/j.1600-0404.1991.tb04974.x


Affiliations:


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